Indications:
Treatment of susceptible protozoal infections such as trichomoniasis, amoebiasis, balantidiasis, Blastocystis hominis infections, giardiasis, dracunculiasis.
Treatment and prophylaxis of anaerobic bacterial infections. Specific bacterial infections include bacterial vaginosis, acute necrotising ulcerative gingivitis, pelvic inflammatory disease and antibiotic-associated colitis.
Eradicate Helicobacter pylori in peptic ulcer disease (in combination with other drugs).
Dosage:
Trichomoniasis: A single 2 g dose or a 7-day course of 250 mg, 3 times daily. Sexual partners should also be treated.
Amoebiasis
- Acute intestinal amoebiasis caused by E. histolytica: Adult: 750 mg, 3 times daily for 5 – 10 days. Children: 35 – 50 mg/kg daily in 3 divided doses for 5 – 10 days.
- Amoebic liver abscess: Adult: 500 – 750 mg, 3 times daily for 5 – 10 days or 1.5 – 2.5 g as a single daily dose for 2 or 3 days. Children: 35 – 50 mg/kg daily in 3 divided doses for 5 – 10 days.
Balantidiasis and Blastocystis hominis infection: 750 mg, 3 times daily for 5 – 10 days, respectively.
Giardiasis: Adult: 2 g once daily for 3 successive days or 250 mg three times daily for 5 – 7 days; children: 15 mg/kg daily in 3 divided doses for 5 – 7 days.
Dracunculiasis: Adult: 250 mg, 3 times daily or 25 mg/kg daily for 10 days; children: 25 mg/kg daily for 10 days, not be exceeded 750 mg daily (include children over 30 kg)
Anaerobic bacterial infections: 5 mg/kg to maximum of 1 g every 6 hours for 7 days or more.
Bacterial vaginosis: A single 2 g dose or as a 5 to 7-day course of 500 mg twice daily.
Acute necrotising ulcerative gingivitis: 250 mg three times daily is given orally for 3 days; similar doses are used in acute oral infections.
Antibiotic-associated colitis: 500 mg, 3 – 4 times daily.
Pelvic inflammatory: 500 mg twice daily in conjunction with ofloxacin given orally in a dosage of 400 mg twice daily; therapy should be continued for 14 days.
Prevention of postoperative anaerobic bacterial infections: 20 – 30 mg/kg daily in 3 divided doses.
- pylori associate peptic ulcer disease: 500 mg, 3 times daily in combination with at least one other agent that has activity against H. pylori (e.g. bismuth subsalicylate, amoxicillin) for 1 – 2 weeks.
Usage:
Metronidazole STELLA 250 mg is administered orally. It’s taken with or after food.