Inidcations
Treatment of Herpes simplex virus (HSV) infections
- Treatment of initial and recurrent HSV infection (type 1 and 2) in mucosa – skin (stomatitis, genital inflammation), in eye (keratitis).
- Prophylaxis of HSV infection in mucosa – skin when recurrences occur at least 6 times a year, in eyes (recurrent keratitis occur after twice a year) or in eye surgery.
Treatment of Varicella zoster virus infection (VZV)
- Herpes zoster, prophylaxis of complications in eye due to zoster in eye.
- Chickenpox in patients more than 2 years of age.
Dosage
- Primary HSV infections, including genital herpes: 200 mg five times daily every 4 hours for 5 – 10 days.
Severely immunocompromised patients or those with impaired absorption: 400 mg five times daily for 5 days
- Suppression of recurrent HSV in immunocompetent patients (at least 6 times/year): 800 mg daily in 2 or 4 divided doses. Reassessment should be performed after 6 – 12 months of treatment.
- Prophylaxis of HSV in immunocompromised patients: 200 to 400 mg four times daily.
- HSV infection in eyes:
Keratitis: 400 mg x 5 times/day in 10 days.
Prophylaxis of recurrence of keratitis (after 3 recurrences a year): 800 mg/day in 2 divided doses. Reassessment should be performed after 6 – 12 months of treatment. Eye surgery: 800 mg/day in 2 divided doses.
- Herpes zoster:
Adults and children > 2 years: 800 mg five times daily may be given for 5 to 10 days.
- Chickenpox:
Adults: 800 mg four or five times daily for 5 to 7 days.
Children > 2 years: 20 mg/kg, not more than 800 mg four times daily for 5 days.
Children from 2 to 5 years: 400 mg four times daily.
Children ≥ 6 years: 800 mg four times daily.
- Renal impairment associated with HIV experienced hemodialysis:
200 – 800 mg every 6 – 8 hours (ClCr 50 – 80 ml/min), every 8 – 12 hours (ClCr 25 – 50 mL/min), every 12 – 24 hours (ClCr 10 – 25 mL/min);
200 – 400 mg every 24 hours (ClCr < 10 mL/min); add 1 dose immediately after hemodialysis.
Usage
Acyclovir STELLA 200 mg is orally taken.
