Partamol 150

OTC

Indications

• For treatment of mild to moderate pain and fever, especially in patients in whom salicylates are contraindicated or not tolerated.
• The drug is most effective in relieving low intensity pain of non-visceral origin.

Dosage

Paracetamol should not be used for self-medication of:

• pain for longer than 5 days in children.
• marked fever (greater than 39.5^oC), fever persisting longer than 3 days, or recurrent fever.
• sore throat pain (pharyngitis, laryngitis, tonsillitis) for longer 2 days in children.

Children may receive is 10 – 15 mg/kg per dose with a maximum of 5 doses per day or the following doses every 4 – 6 hours as necessary (up to 5 times in 24 hours) with normally dosages:

• Children 11 years of age (weighing 32.5 – 43 kg): 480 mg (about 3 sachets), repeated if necessary after interval of 4 hours, without exceeding 12 sachets per day.
• Children 9 – 10 years of age (weighing 27 – 32.5 kg kg): 400 mg (about 2.5 sachets), repeated if necessary after interval of 6 hours, without exceeding 12 sachets per day.
• Children 6 – 8 years of age (weighing 21.5 – 27 kg): 320 mg (about 2 sachets), repeated if necessary after interval of 4 hours, without exceeding 8 sachets per day.
• Children 4 – 5 years of age (weighing 16 – 21.5 kg): 240 mg (about 1.5 sachets), repeated if necessary after interval of 6 hours, without exceeding 8 sachets per day.
• Children 2 – 3 years of age (weighing 11 – 16 kg): 160 mg (about 1 sachets), repeated if necessary after interval of 4 hours, without exceeding 6 sachets per day.
• Children 12 -23 months of age (weighing 8 – 11 kg): 120 mg (about 1 sachets), repeated if necessary after interval of 6 hours, without exceeding 4 sachets per day.

Usage

• Partamol 150 is administered orally.
• The effervescent granules must be dissolved in water and the solution should then be drunk after complete dissolution of the granules.

• Patients with anemia or cardiac, pulmonary, renal, or hepatic disease.
• Patients with alcohol dependence.
• Patients with known hypersensitivity to paracetamol or any of the excipients listed in.
• Patients with known glucose – 6 – phosphate dehydrogenase deficiency.

Uncommon

• Rash, nausea, vomiting,
• Bblood dyscrasias (neutropenia, pancytopenia, leukopenia), anemia,
• Nephropathy, nephrotoxicity with chronic abuse.

• Paracetamol should be used with caution in patients with preexisting anemia, since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.
• Excessive intake of alcohol may increase the risk of paracetamol induced hepatotoxicity; avoid or limit alcohol intake.
• Caution is recommended when giving to patients with hepatic or renal impairment, susceptible individuals.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Partamol 150 contains aspartame. Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
• Partamol 150 contains saccharose (sucrose). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
• Infrequent paracetamol should remain the analgesic of choice in pregnancy. Caution when use paracetamol for breastfeeding women.
• Patients should be aware of how they react to Partamol 150 before driving or operating machinery.