Partamol 500 CAP

OTC

Indications

• For the treatment of headaches including migraine and tension headaches;
• Also for backache, rheumatic and muscle pains, nerve pains, toothache, dysmenorrhoea, sore throat and for relieving the fever, aches and pains of colds and flu.

Dosage

• Adults, elderly and children over 16 years:
  02 capsules up to 4 times a day.
  Do not take for more than 3 days without consulting your doctor.
  These doses should not be repeated more frequently than every 4 hours and not more than 4 doses should be given in any 24 hour period.
• Children aged 10 to 15 years:
  One capsule every four to six hours when necessary to a maximum of four doses in 24 hours.
  Do not take for more than 3 days without consulting your doctor.
• Not recommended for children under 10 years of age.

Usage

• For oral administration.

• Patients with known hypersensitivity to paracetamol or to any of the other ingredients.
• Severe hepatic impairment.

• Serious skin reactions such as Stevens-Johnson syndrome, Lyell’s syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis occur rarely, but potentially fatal. If patients get a rash or other skin manifestations, to stop taking drug and notify your physicians.
• Skin rash and other allergic reactions occur occasionally. The rash is usually erythematosus or urticarial, but sometimes it is more serious and may be accompanied by fever and mucosal lesions. If patients have fever, blisters around the natural cavity, consider Stevens-Johnson syndrome, be discontinued paracetamol immediately.
• Paracetamol overdose can lead to severe liver damage and sometimes acute tubular necrosis. Patients who show hypersensitivity reactions to the salicylates only rarely exhibit sensitivity to paracetamol and related drugs. In a few isolated cases, the use of paracetamol has been associated with neutropenia, thrombocytopenia and pancytopenia.

• Not recommended for children under the age of 10 years.
• Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
• Do not exceed the recommended dose. Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.
• Do not take with any other paracetamol-containing products.
• If symptoms persist consult your doctor.
• Keep out of the reach of children.
• Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, mainutrition and other sources of glutathione deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is recommended.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• Paracetamol should be only used in pregnant and nursing women when clearly needed.
• There is no evidence that paracetamol affects the ability to drive or to operate machinery.