Pamidstad 2.5

Rx

Indications:

• The treatment of essential hypertension (use in monotherapy or in combination with other hypotensive agents)
• The treatment of salt and fluid retention associated with congestive heart failure. In acute, severe left sided heart failure, more potent diuretics such as bumetanide or furosemide should be used initially.

Dosage:

Adults, elderly (when renal function is normal or only minimally impaired)

• For hypertension: One tablet daily taken in the morning (the action of indapamide is progressive and the reduction in blood pressure may continue and not reach a maximum until several months after the start of therapy). If a single daily tablet of indapamide does not achieve a sufficient reduction in blood pressure, indapamide can be used in combination with beta-blockers, ACE inhibitors, methyldopa, clonidine and other adrenergic blocking agents. A larger dose than 2.5 mg indapamide daily is not recommended. The co-administration of indapamide with diuretics which may cause hypokalaemia is not recommended.
• For treatment of salt and fluid retention associated with congestive heart failure: The usual dosage is 2.5 mg indapamide given as a single dose daily, increasing to 5 mg daily after 1 week if necessary.

Children and adolescents: Not recommended for use.

Usage:

Pamidstad 2.5 is administered orally. The tablet must be taken wholly, not broken, chewed or crushed.

Known hypersensitivity to any of the active substance or excipients. Severe renal failure. Hepatic encephalopathy or severe impairment of liver function. Hypokalaemia. Pregnancy and lactation.

Common:

Hypersensitivity reactions, maculopapular rashes.

Not known:

Potassium depletion with hypokalaemia, hyponatraemia; syncope; myopia, blurred vision, visual impairment; Torsade de pointes; Possibility of onset of hepatic encephalopathy in case of hepatic insufficiency; Possible worsening of pre-existing acute disseminated lupus erythematosus, photosensitivity reactions; Electrocardiogram QT prolonged, blood glucose increased, blood uric acid increased, elevated liver enzyme levels.

Water and electrolyte balance before and during treatment with indapamide.

Indapamide may give a positive reaction in doping tests.

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Ponceau 4R lake may cause allergic reactions.

Avoid using indapamide for pregnancy and lactation.

Treatment should be stop immediately: (1) If hepatic encephalopathy occurs in patients with liver impairment, photosensitivity reactions occur during treatment. If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA. (2) Treatment should be withdrawn before the investigation of parathyroid function.

Patients should be aware of how they react to drug before driving or operating machinery.