PARTAMOL 250 EFF.

OTC

Indications

• For treatment of mild to moderate pain and fever, especially in patients in whom salicylates are contraindicated or not tolerated.
• The drug is most effective in relieving low intensity pain of non-visceral origin.

Dosage

• Paracetamol should not be used for self-medication of pain for longer than 5 days in children, marked fever (greater than 39.5^oC), fever persisting longer than 3 days, or recurrent fever.
  Adults: 0.5 – 1 g (2 – 4 sachets) every 4 – 6 hours to a maximum of 4 g daily.
  Children: Every 4 – 6 hours as necessary.
  1 – 6 years: 120 – 250 mg (1/2 – 1 sachets) to a maximum 4 g doses in 24 hours.
  6 – 12 years: 250 – 500 mg (1 – 2 sachets) to a maximum 4 g doses in 24 hours.
  12 – 18 years: 500 mg (2 sachets).

Usage

• PARTAMOL 250 EFF. is administered orally.
• The effervescent granules must be dissolved in water and the solution should then be drunk after complete dissolution of the granules.

• Patients with anemia or cardiac, pulmonary, renal, or hepatic disease.
• Patients with alcohol dependence.
• Patients with known hypersensitivity to paracetamol or to any of the excipients listed in.
• Patients with known glucose – 6 – phosphate dehydrogenase deficiency.

Adverse effects of paracetamol are usually rare and mild.

• Rash,
• Neutropenia, pancytopenia, leukopenia, anemia,
• Nephropathy, nephrotoxicity with chronic abuse,
• Asthma,
• Angioedema, eruptions.

• Paracetamol should be used with caution in patients with preexisting anemia, since cyanosis may not be apparent despite dangerously high blood concentrations of methemoglobin.
• Excessive intake of alcohol may increase the risk of paracetamol induced hepatotoxicity; avoid or limit alcohol intake.
• Caution is recommended when giving to patients with hepatic or renal impairment, susceptible individuals.
• The physicians need to warn the patients of the signs of serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) or Lyell’s syndrome, acute generalized exanthematous pustulosis (AGEP).
• PARTAMOL 250 EFF. contains aspartame. Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up because the body cannot remove it properly.
• PARTAMOL 250 EFF. contains saccharose (sucrose). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
• PARTAMOL 250 EFF. contains sunset yellow lake which may cause allergic reactions.
• Infrequent paracetamol should remain the analgesic of choice in pregnancy. Caution when use paracetamol for breastfeeding women.
• Patients should be aware of how they react to PARTAMOL 250 EFF. before driving or operating machinery.