Perindastad 4

Rx

Indications

• Hypertension;
• Symptomatic heart failure,
• Reduction of risk of cardiac events in patients with a history of myocardial infarction and/or revascularization.

Dosage

• Hypertension
  Perindopril may be used in monotherapy or in combination with other classes of antihypertensive therapy. Commence with 4 mg, may be increased to 8 mg once daily after one month. Elderly patients commence with 2 which may be progressively increased to 4 mg after one month then to 8 mg if necessary depending on renal function.
• Symptomatic heart failure
  Start with 2 mg, may be increased by increments of 2 mg at intervals of no less than 2 weeks to 4 mg once daily if tolerated.
• Stable coronary artery disease
  Start with 4 mg once daily for two weeks, then increased to 8 mg once daily, depending on renal function and provided that 4 mg dose is well tolerated.
  Elderly patients should receive 2 mg once daily for one week, then 4 mg once daily the next week, before increasing the dose up to 8 mg once daily depending on renal function.
  Patients with renal impairment:
  + ClCr 30-60 ml/min: 2 mg/day;
  + ClCr 15 – 30 ml/min: 2 mg, every other day; haemodialysed patients (dialysis clearance of perindoprilat is 70 ml/min, the dose should be taken after dialysis)
  + ClCr < 15 ml/min: 2 mg on the day of dialysis.

Usage

• It is orally taken once daily in the morning before a meal.

• Known hypersensitive to any of the active substance or excipients.
• History of angioedema related to previous ACE inhibitors treatment.
• Hereditary or idiopathic angioedema.
• The concomitant use of perindopril with aliskiren containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/ 1.73 m²).
• Pregnancy and lactation.

• Headache, disorders of mood and/or sleep disorders, asthenia;
• Blood pressure not sufficiently controlled at the start of treatment;
• Non-specific GI disorders, taste alteration, vertigo, cramp;
• Urticaria;
• Dry cough, irritative type.

• Patients with volume or salt restriction, prolonged diuretic therapy, dialysis, diarrhea, or vomiting, congestive heart failure.
• Patients with unilateral or bilateral renal artery stenosis, preexisting renal impairment, or concomitant diuretic therapy.
• Patients with renal impairment, diabetes mellitus, those receiving drugs that can increase serum potassium concentration.
• Patients undergoing surgery or during anesthesia with agents that produce hypotension.
• Patients should be aware of how they react to drug before driving or operating machinery.