Spirastad 1.5 M.I.U

Rx

Indications

• Infectious conditions in respiratory, cutaneous and genital tracts caused by sensitive organisms.
• Prophylaxis of meningitis caused by Meningococci in patients with contraindication to rifampicin.
• Prevention of congenital toxoplasmosis during pregnancy.
• Chemoprophylaxis of recurrent acute rheumatic arthritis in patients allergic to penicillins.

Dosage

• Adults: 5 million – 3 million IU, 3 times daily.
• Infants and children: 150 thousand IU/kg daily, in 3 divided doses.

Prophylaxis of meningitis due to Meningococci

• Adults: 3 million IU every 12 hours.
• Children: 75 thousand IU/kg every 12 hours for 5 days.

Prevention of congenital toxoplasmosis during pregnancy

• 9 million IU daily in divided doses for 3 weeks, repeated 2-weekly intervals.
• Combination or alternation with a pyrimethamine/sulfonamide regimen may improve results.

Usage

• Spirastad 1.5 M.I.U is administered orally. Because food in the stomach reduces the bioavailability of spiramycin, the dose should be administered at least 2 hours before or 3 hours after a meal.
• Patients taking spiramycin should comply with the full course of therapy.

Patients with known hypersensitivity to spiramycin, erythromycin or to any ingredient in the formulation.

Common

• Nausea, vomiting, diarrhea, indigestion.

Uncommon

• Fatigue, epistaxis, sweating, heaviness in the chest, transient paresthesias, dysesthesia, giddiness, pain, muscular and knuckle stiffness;
• Acute colitis;
• Rash, exanthema, urticaria.

• Spiramycin should be used cautiously in patients with hepatic dysfunction;
• Pregnant women.
• Mothers should discontinue breast feeding during spiramycin administration.