Keamine

Rx

Indications

• Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of < 40 g/day (for adults); generally in patients with a glomerular filtration rate (GFR) < 25 mL/min.

Dosage

• Adults (70 kg body weight): 4 – 8 tablets 3 times a day during meals.
• Keamine are given as long as the glomerular filtration rate (GFR) is < 25 mL/min and a diet with an intake of maximum 40 g protein/day is followed.

Usage

• Keamine is administered orally. Tablets should be swallowed whole and should not be crushed or chewed.

• Hypercalcaemia, disturbed amino acid metabolism.
• In case of hereditary phenylketonuria it has to be taken into account that Keamine contains phenylalanine.
• Pregnancy and paediatric.

• Hypercalcaemia may develop. In this case, it is recommended to decrease vitamin D intake. If the hypercalcaemia persists, reduce the dosage of Keamine as well as any other source of calcium.

• Keamine should be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level should be monitored regularly.
• Ensure the sufficient supply with calories for the patients.
• Pregnancy and lactation.
• Patients should be aware of how they react to drug before driving or operating machinery.