Metronidazole STELLA 250 mg

Rx

Indications

• Treatment of susceptible protozoal infections such as trichomoniasis, amoebiasis, balantidiasis, Blastocystis hominis infections, giardiasis, dracunculiasis.
• Treatment and prophylaxis of anaerobic bacterial infections. Specific bacterial infections include bacterial vaginosis, acute necrotising ulcerative gingivitis, pelvic inflammatory disease and antibiotic-associated colitis.
• Eradicate Helicobacter pylori in peptic ulcer disease (in combination with other drugs).

Dosage

• Trichomoniasis
  A single 2 g dose or a 7-day course of 250 mg, 3 times daily. Sexual partners should also be treated.
• Amoebiasis
  Acute intestinal amoebiasis caused by E. histolytica: Adult: 750 mg, 3 times daily for 5 – 10 days. Children: 35 – 50 mg/kg daily in 3 divided doses for 5 – 10 days.
  Amoebic liver abscess: Adult: 500 – 750 mg, 3 times daily for 5 – 10 days or 1.5 – 2.5 g as a single daily dose for 2 or 3 days. Children: 35 – 50 mg/kg daily in 3 divided doses for 5 – 10 days.
• Balantidiasis and Blastocystis hominis infection
  750 mg, 3 times daily for 5 – 10 days, respectively.
• Giardiasis
  Adult: 2 g once daily for 3 successive days or 250 mg three times daily for 5 – 7 days;
• Dracunculiasis
• Anaerobic bacterial infections
  5 mg/kg to maximum of 1 g every 6 hours for 7 days or more.
• Bacterial vaginosis
  A single 2 g dose or as a 5 to 7-day course of 500 mg twice daily.
• Acute necrotising ulcerative gingivitis
  250 mg three times daily is given orally for 3 days; similar doses are used in acute oral infections.
• Antibiotic-associated colitis
  500 mg, 3 – 4 times daily.
• Pelvic inflammatory
  500 mg twice daily in conjunction with ofloxacin given orally in a dosage of 400 mg twice daily; therapy should be continued for 14 days.
• Prevention of postoperative anaerobic bacterial infections
  20 – 30 mg/kg daily in 3 divided doses.
• H. pylori associate peptic ulcer disease
  500 mg, 3 times daily in combination with at least one other agent that has activity against H. pylori (e.g. bismuth subsalicylate, amoxicillin) for 1 – 2 weeks.

Usage

• Metronidazole STELLA 250 mg is administered orally. It’s taken with or after food.

• Hypersensitivity to other nitroimidazole derivatives or to any ingredient of the drug.
• The first trimester of pregnancy.

Common

• Nausea, vomiting, anorexia, abdominal pain, diarrhoea and unpleasant metallic taste.

• Mild disulfiram – like reactions including flushing, headache, nausea, vomiting, abdominal cramps, and sweating.
• Clinical and laboratory monitoring is advised if treatment exceeds 10 days.
• Used with caution and in reduced dosage in patients with severe hepatic impairment. Plasma concentration of metronidazole should be monitored in such patients.
• Patients with wheat allergy (different from coeliac disease) should not take this medicine.
• Pregnancy/ lactation: Only use when clearly needed.
• Patients should be aware of how they react to drug before driving or operating machinery.